Abstract
Magnetite nanoparticles (MNP) were synthesized and stabilized with carboxylated compounds citric acid – CA, poly(acrylic acid) – PAA, poly(acrylic acid-co-maleic acid) – PAM, humic acid – HA and gallic acid – GA (polymerizing in situ on the surface). Adsorption isotherms and bonding feature were determined and used to explain the changes in charge and aggregation states and salt tolerance of the MNPs. The thicker layer of macromolecular acids PAA, PAM and HA provides better stability at physiological pH and salt concentration compared to the CA and GA coatings. In addition, Fe(III)-CA complexation promotes the dissolution of the nanoparticles. The biocompatibility of the polyacid-coated MNPs was tested in cell proliferation experiments.
Highlights
Magnetite nanoparticles (MNPs) are superparamagnetic iron oxide nanoparticles that have been applied efficiently in a number of various biomedical applications such as MRI contrasting, targeted drug delivery and hyperthermia as discussed recently in a review paper [1]
With the exception of PAA, are of high affinity (H-type isotherms) and the affinity increases in the order Citric acid (CA) ~ gallic acid (GA) < PAM < Humic acid (HA)
After the high-affinity limit at ~0.1 mmol/g, the adsorption of both CA and GA continues without reaching a plateau value
Summary
Magnetite nanoparticles (MNPs) are superparamagnetic iron oxide nanoparticles ( called SPIONs) that have been applied efficiently in a number of various biomedical applications such as MRI contrasting, targeted drug delivery and hyperthermia as discussed recently in a review paper [1]. The colloidal stability of MFs under physiological conditions (blood pH~7.2–7.4 and salt concentration ~0.15 M) and in high magnetic field gradient is of crucial importance Most of these applications require the magnetic nanoparticles to be nontoxic, chemically stable, uniform in size, and well-dispersed in aqueous media [1,2]. The chemical interactions between the ≡Fe–OH sites and the adsorbed carboxylic groups are specific, and so their bond strengths differ significantly from each other Their stabilizing efficiency changes definitely due to the different structure and thickness of the coating layers on the MNPs, i.e., the different composition of the aqueous interface at the particle surface. The interaction of these carboxylated MFs with human plasma has been studied within the framework of ESF network program Epitopmap in Dublin, the results of which have been published recently [7]
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