Abstract
In this article, we offer a summary of a broad variety of colloidal drug delivery systems with a special emphasis on vesicular used in testing or theoretically useful as carrier systems for medicines or active biomolecules or as cell carriers with therapeutic use. They provide several significant details of the currently developed drug delivery systems for academic or clinical applications. This series of systems are commonly used due to outstanding drug tracking, continuous and regulated release behavior, improved drug molecules clogging performance, avoidance of product hydrolysis or enzymatic degradation, and therapeutic efficacy improvements. Such characteristics aid in the discovery of suitable carrier structures for the transmission of medicines, cells, and genes in various fields. Colloidal drug delivery systems play a significant role in drug delivery. In my opinion, all colloidal carriers present notable characteristics after application. These vesicles can deliver an active compound through the biological membranes via absorption, fusion, and to raise the quantity of permeated drugs compared with conventional formulations.
Highlights
Starch Drug delivery challenges include poor drug solubility, poor bioavailability, peptide and protein delivery, large particle size, in vivo stability, intestinal absorption, sustained and targeted delivery to the site of action, therapeutic efficacy, generalized side effects, and drug plasma fluctuation (Kayser et al, 2005). Such problems are solved by many modern drug delivery systems, using bioadhesive systems, transdermal patches, nanoscale devices, implants, microparticulate systems and even the path to delivery as nasal or buccal DDSs
Similar to liposomes and niosomes, spanlastic systems are spherical shaped structures consisting of amphiphilic molecules that function as appropriate media for bioencapsulation (Balakrishnan et al, 2009)
The third type is multiple form in which the solubility in liquid lipid is greater than in solid lipid, while preserved by solid lipid from decomposition. This type of Nano structure lipid carrier (NLC) is identical to the emulsions w / o / w.(Lakshmi PK, Kalpana B, 2013)
Summary
Nahed Sallama, Rania Sanada, El-Sayed Khafagy b, Ahmed Mahgoubc, Mamdouh Ghourabb, Shadeed Gadb aDepartment of Pharmaceutics, National Organization for Drug Control and Research, Egypt; bDepartment of Pharmaceutics, Faculty of Pharmacy, Suez Canal University, Egypt; cDepartment of Molecular Drug Evaluation, National Organization for Drug Control and Research, Egypt.
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