Abstract
The successful application of sedimentation field-flow fractionation (sedimentation FFF) to the characterization of monodisperse and polydisperse particle populations was extended to the determination of the droplet size distribution (DSD) of emulsions. The theory and advantages of sedimentation FFF are briefly reviewed, and it is shown quite generally that the centrifugal field is not sufficiently strong to cause droplet distortion, aggregation, or other similar disturbances. Two different sets of experiments, applied to two commercial emulsions used for intravenous nutrition, are described. The safflower oil emulsion, subjected primarily to self-consistency tests, was shown to yield virtually identical raw DSD curves despite changes in field strength, sample size, flow velocity, and instrumental systems. For the soybean oil emulsion, a detector response correction factor was obtained by dissolution of the emulsion. It was shown that changes in the manufactured emulsion product could be followed by directly observing changes in the fractogram, or by noting changes in the DSD curves. The conditions under which the different kinds of curves can be used for comparative purposes were outlined.
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