Collodion babies: A 15-year retrospective multicenter study in The Netherlands—Evaluation of severity scores to predict the underlying disease

Abstract

To the Editor: The clinical phenotype of a collodion baby can be caused by many ichthyosis subtypes of different severities. When genetic analysis is not possible or when diagnosis is unknown, clinical evaluation is essential to identify the more severe syndromic subtypes of ichthyosis in which other organ systems besides skin can be affected. Rubio-Gomez et al1 proposed a clinical scoring system based on collodion penotype based on 15 characteristics and concluded that an extensive collodion membrane was predominantly related to a nonsyndromic ichthyosis.