Abstract
There have been some reports of coincidental presentation of breast carcinoma and phyllodes tumor in the same breast. Most of the cases were carcinoma that arose from a phyllodes tumor with a histologically identified transitional area, and they behaved less aggressively than the usually encountered carcinoma. Collision tumors are rare clinical entities in which two histologically distinct tumor types show involvement at the same site. The occurrence of these tumors in the breast is extremely rare. Here, we report a case of 45-year-old woman who had both invasive ductal carcinoma as the finding of inflammatory carcinoma and a malignant phyllodes tumor in the same breast. There was no evidence of a transitional area between the phyllodes tumor and the invasive ductal carcinoma. To our knowledge, this is the first report of a collision tumor of inflammatory breast carcinoma coincident with a malignant phyllodes tumor in same breast.
Highlights
Collision tumors are rare clinical entities in which two histologically distinct tumor types show involvement in the same site
The presentation of carcinoma and other tumors in same breast as a finding of collision tumor is extremely rare, and there have been few reports of collision tumor consisting of invasive ductal carcinoma admixed with breast mucosa-associated lymphoid tissue lymphoma [3], chronic lymphocytic leukemia and lactating adenoma [4]
* Correspondence: yj0139@naver.com 2Department of Surgery, Eulji University Hospital, Eulji University School of Medicine, Dunsan-dong 1306, Seo-gu, Daejeon 135-710, Korea Full list of author information is available at the end of the article invasive carcinoma in the same breast, is extremely rare;in a review of the literature, we found three cases of collision tumor with malignant Phyllodes tumors (PT) and invasive carcinoma [8,9,10]
Summary
Collision tumors are rare clinical entities in which two histologically distinct tumor types show involvement in the same site. Macroscopic examination of the resection specimen revealed a firm and well-demarcated mass with hemorrhage and necrosis, measuring approximately 24 cm in the largest dimension (Figure 3a) This mass was composed of two separated tumorous lesions: phyllodes tumor and invasive carcinoma of no special type. Six months after the operation, and after completion of eight cycle’s chemotherapy, the patient developed left supraclavicular and upper chest wall swelling, which was consistent with regional aggravation of metastatic carcinoma and was supported by image findings. She underwent a session of radiation therapy to the chest wall and neck, and platinum-based chemotherapy will be pursued in this patient as further treatment. She is doing well with good compliance to the chemotherapy and radiation therapy
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