Collective Cell Migration in Development.

Abstract

Collective cell migration is a key process in developmental biology, facilitating the bulk movement of cells in the morphogenesis of animal tissues. Predictive understanding in this field remains challenging due to the complexity of many interacting cells, their signalling, and microenvironmental factors - all of which can give rise to non-intuitive emergent behaviours. In this chapter we discuss biological examples of collective cell migration from a range of model systems, developmental stages, and spatial scales: border cell migration and haemocyte dispersal in Drosophila, gastrulation, neural crest migration, lateral line formation in zebrafish, and branching morphogenesis; as well as examples of developmental defects and similarities to metastatic invasion in cancer. These examples will be used to illustrate principles that we propose to be important: heterogeneity of cell states, substrate-free migration, contact-inhibition of locomotion, confinement and repulsive cues, cell-induced (or self-generated) gradients, stochastic group decisions, tissue mechanics, and reprogramming of cell behaviours. Understanding how such principles play a common, overarching role across multiple biological systems may lead towards a more integrative understanding of the causes and function of collective cell migration in developmental biology, and to potential strategies for the repair of developmental defects, the prevention and control of cancer, and advances in tissue engineering.