Abstract

To determine the value of susceptibility-weighted imaging (SWI) for collateral estimation and for predicting functional outcomes after acute ischemic stroke. To identify independent predictors of favorable functional outcomes, age, sex, risk factors, baseline National Institutes of Health Stroke Scale (NIHSS) score, baseline diffusion-weighted imaging (DWI) lesion volume, site of steno-occlusion, SWI collateral grade, mode of treatment, and successful reperfusion were evaluated by multiple logistic regression analyses. A total of 152 participants were evaluated. A younger age (adjusted odds ratio (aOR), 0.42; 95% confidence interval (CI) 0.34 to 0.77; P < 0.001), a lower baseline NIHSS score (aOR 0.90; 95% CI 0.82 to 0.98; P = 0.02), a smaller baseline DWI lesion volume (aOR 0.83; 95% CI 0.73 to 0.96; P = 0.01), an intermediate collateral grade (aOR 9.49; 95% CI 1.36 to 66.38; P = 0.02), a good collateral grade (aOR 6.22; 95% CI 1.16 to 33.24; P = 0.03), and successful reperfusion (aOR 5.84; 95% CI 2.08 to 16.42; P = 0.001) were independently associated with a favorable functional outcome. There was a linear association between the SWI collateral grades and functional outcome (P = 0.008). Collateral estimation using the prominent vessel sign on SWI is clinically reliable, as it has prognostic value.

Highlights

  • To determine the value of susceptibility-weighted imaging (SWI) for collateral estimation and for predicting functional outcomes after acute ischemic stroke

  • Our study showed a positive correlation between the SWI collateral grade and collateral-perfusion grade determined by the multiphase MR angiography collateral map (P < 0.001) and a linear negative association between the SWI collateral grades and functional outcomes (P = 0.008)

  • We demonstrated that the significant predictors of a favorable functional outcome in acute ischemic stroke due to occlusion or stenosis of the unilateral internal carotid artery (ICA) and/ or M1 segment of the middle cerebral artery (MCA) within 8 h of symptom onset were a younger age, lower baseline National Institutes of Health Stroke Scale (NIHSS) scores, and smaller baseline diffusion-weighted imaging (DWI) lesion volume, an intermediate and good SWI collateral grade and reperfusion

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Summary

Introduction

To determine the value of susceptibility-weighted imaging (SWI) for collateral estimation and for predicting functional outcomes after acute ischemic stroke.

Results
Conclusion
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