Abstract
In article number 1901299, Chunsheng Kang and co-workers demonstrate the collateral effect of the CRISPR-Cas13a system in glioma cells. EGFRvIII is a unique EGFR mutant subtype in glioma, and the CRISPR-Cas13a system induces death in EGFRvIII-overexpressing glioma cells. Furthermore, CRISPR-Cas13a inhibits the formation of glioma intracranial tumors in mice. The results indicate the powerful tumor eliminating potential of this system.
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