Abstract
ollagenous and Iymphocytic colitis IL,. are clinicopathologic syndromes of watery diarrhea with normal colono scopy and colonic inflammation'. Both constitute a third type of colitis after inflammatory bowel disease (1131)). Collagenous colitis(CC) shares histological and clinical similarities to lymphocytic colitis (LC), also called microscopic colitis, Thus, both diseases will be discussed here. The terminology remains somewhat controversial. The term 'microscopic colitis', while not recognized by some authorities, generally refers to a group of disorders, but still some consider microscopic colitis as synonymous to lymphocytic colitis. Because of the similarities of these two disorders, they are commonly considered a single category for the purposes of treatment and are referred to as microscopic colitis. it is not known whether LC and CC represent different clinical entities or constitute part of a spectrum of the same disease. Some said
Highlights
Collagenous and lymphocytic colitis are clinicopathologic syndromes of watery diarrhea with normal colonoscopy and colonic inflammation[1]
The finding of fecal leukocytes in 55% of patients with collagenous colitis confirms the inflammatory basis of this disease[10]
Watery diarrhea up to 5 liters per day may occur for a period ranging from 5 up to 20 years, yet sometimes may present in patients with relatively brief duration of diarrhea[15]
Summary
Collagenous and lymphocytic colitis are clinicopathologic syndromes of watery diarrhea with normal colonoscopy and colonic inflammation[1]. Possible causes are: unidentified chronic gastrointestinal infections, immune disturbance including autoimmune diseases, medications (e.g. some nonsteroidal anti-inflammatory drugs (NSAIDS), ranitidine and carbemazepine)[1,6]. The finding of fecal leukocytes in 55% of patients with collagenous colitis confirms the inflammatory basis of this disease[10].
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