Abstract
Abstract 1. 1. Two collagenolytic proteinases have been isolated from the starfish, Pycnopodia helianthoides and partially characterized. 2. 2. The larger of these two enzymes, with a molecular weight of approx 60,000, resembles the vertebrate collagenases in that it is inhibited by ethylenediamine tetraacetate and is able to cleave the collagen triple-helix. 3. 3. The smaller enzyme, with a mol. wt of approximately 16,500, resembles the vertebrate chymotrypsins in its ability to hydrolyse acetyl-tyrosine-ethylester and its cleavage of collagen in the telopeptide region. 4. 4. Other properties of the enzymes, including alkaline pH optima, acidic isoelectric point and heat stability are similar for both proteinases.
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