Abstract
Collagenolytic activity in synovial tissue was studied by measuring the degradation of collagen in normal and rheumatoid synovial tissue samples. In the assay the 6000- g pellet of the tissue homogenate was incubated in neutral buffer in the presence of Ca 2+ at 37° for 20 h. Released hydroxyproline-containing material was taken as the measure of collagenolytic activity. The mean value of collagenolytic activity in the rheumatoid arthritis group was about 6–7 times that of controls. High values were found in patients having elevated rheumatoid factor titres. The increased collagenolytic activity in rheumatoid synovial tissue suggests increased breakdown of collagen in the diseased synovium. The high collagenolytic activity in the synovium may be connected with the local tissue destruction in the joint.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
