Collagen‐Coated Lapatinib‐Loaded Poly(lactic acid) Microspheres for Breast Cancer in Biomedical Applications

Abstract

ABSTRACTA novel micro in situ drug loaded with poly(lactic acid) (PLA) microspheres coated with collagen by a simple adsorption technique through the water‐in‐oil emulsion method is introduced to reduce inflammatory responses at the site of implants and enhance the bioactiveness for several applications in the medical field including tissue engineering. The surface modification technique was the current scenario; hence, the protein adsorption principle is used for coating of collagen onto the surface of PLA microspheres. The study was conducted in two steps: (1) Lapatinib drug loaded PLA microspheres were prepared and characterized and (2) the drug‐loaded PLA microspheres were dispersed in a collagen solution, yielding the modified microspheres. The surface morphology of the prepared PLA microspheres was verified by using a scanning electron microscope, and it is concluded that the microspheres are spherical in shape. The PLA microspheres are studied through attenuated total reflectance Fourier transform infrared spectroscopy, and through the differential scanning calorimetry–thermal gravimetric analysis technique it is observed that there is no interaction between polymer and the drug. The in vitro release study of modified PLA microspheres was conducted at pH 7.4, and the results indicated that the adsorption technique can be the simple strategy to coat collagen on the surface of polyester implants to develop the stealth implant in shorter time with low cost technology.