Abstract
Collagen is the predominant organic constituent of bone, cementum, periodontal membranes, and gingiva. For this reason, it is the major protein destroyed during the course of periodontal diseases. Although for many years degradation of collagen has been known to occur as part of the process of periodontitis, demonstration of specific collagenase, derived from periodontal tissues and capable of acting at physiologic pH and ionic strength, has been recent.1-6 Discovery of the enzyme required the use of a tissue culture system. Previous investigators searching for collagenase in vertebrate tissues had examined homogenates without success.7'8
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