Abstract

Collagens in the cervix (type I) and chorioamniotic membranes (type I, IV) play important biomechanical roles in maintaining healthy pregnancy and undergo significant modulation during natural labour progression. However, timing is key: inappropriate remodeling of collagens can trigger premature cervical dilation, chorioamniotic membrane rupture and preterm labour. While up to 40% of preterm labour cases arise from microbial infection, the mechanisms underlying this process are not understood. Notably, select members of the vaginal microbiome have been significantly associated with preterm labour including Sneathia, Prevotella and Porphyromonas species.

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