Abstract
Periodontal diseases ranges from simple gum inflammation to serious disease that consists in major damage to the soft tissue and bone teeth support. Periodontal diseases affects the marginal and apical periodontium and results from the interaction between bacterial biofilm and the host response. To determine the concentrations of MMP-8, as a disease marker, in saliva in prosthetic and nonprosthetic, aggressive (AP) and chronic (CP) periodontitis, doxycycline treated patients. 40 patients were distributed into 3 groups: 12 diagnosed with aggressive (AgP), 18 with chronic (CP) periodontitis. Each of these groups was subdivided into 2 subgroups with and without fixed prosthesis. 10 patients were in the normal group. Matrix metalloproteinase 8 (MMP-8) was evaluated before and after systemic doxycycline (Dox) treatment. mean MMP-8 value into the control group was 0.57 ng/mL with a standard deviation (STD) of 0,094 ng/mL. Highest MMP-8 value was established for the nonprosthesis AgP subgroup, before Dox treatment. The highest reduction in MMP-8 levels (40.8%) was between nonprosthesis AgP before Dox treatment and the same group after Doxycycline treamtent. MMP-8 saliva levels are lower than GCF levels, mostly through a dilution mechanism as previous studies had shown. Our study revealed that saliva MMP-8 level is relible marker for AgP but not for CP. Doxycycline treatment, in terms of lowering MMP-8 levels is most effective in patients that have AP and are also wearing fixed.
Highlights
It has been established that periodontal disease results from the imbalance between oral microbiota with its antigens on one side and the pateint’s mainly neutrophil and macrophage involved nonspecific inflamatory reaction (NIR) on the other [1,2,3,4]
The tests that are used in periodontal diagnosis, laborious and time consuming, are: probing depth (PD), clinical atachement level (CAL), bleeding on probing, plaque index and radiographic recordings and tend to express the consequences of the disease not the current status of the periodontium, these tests cannot predict the future destruction of the P or the response to treatment. [10,11,12,13]
The mainstay for periodontitis treatment is represented by the mechanical debridement followed by local or systemic use of antibiotics, doxycycline (Dox) at just 20 mg twice daily dose inducing a significant reduction in neutrophil colagenase gingival crevicular fluid (GCF) concentrations, with the local administration route being the best way in terms of gastrointestinal side effects, microbial antibiotic resistance, patient cooperation and other medication interaction [19]
Summary
ANDRA AUNGURENCEI1, IONUT LUCHIAN2*, ANCUTA GORIUC3*, DANA CONSTANTINESCU4, IOANA MARTU1, DIANA DIACONU POPA1, ANCA VITALARIU1, DIANA LUCHIAN5, KAMEL EARAR6, MONICA TATARCIUC1 1University of Medicine and Pharmacy Grigore T. To determine the concentrations of MMP-8, as a disease marker, in saliva in prosthetic and nonprosthetic, aggressive (AP) and chronic (CP) periodontitis, doxycycline treated patients. The highest reduction in MMP-8 levels (40.8%) was between nonprosthesis AgP before Dox treatment and the same group after Doxycycline treamtent. The mainstay for periodontitis treatment is represented by the mechanical debridement followed by local or systemic use of antibiotics, doxycycline (Dox) at just 20 mg twice daily dose inducing a significant reduction in neutrophil colagenase GCF concentrations, with the local administration route being the best way in terms of gastrointestinal side effects, microbial antibiotic resistance, patient cooperation and other medication interaction [19]. Our study focused on saliva MMP8 levels surveyed in patients with aggresive (AP) and chronic periodontitis (CP) before and after Dox treatment
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