Abstract
Chondrocytes grown in monolayer culture from the joints of young rabbits synthesized collagen provided that ascorbic acid (50 μg/ml) was present in the nutrient medium. The collagen formed in vitro by whole articular cartilage was composed of α1 chains only, suggesting a chain composition [α1(II)] 3. By contrast the collagen produced by the cultured chondrocytes contained both α1 and α2 chains with a varying chain ratio (α1:α2 usually 2:1; occasionally as high as 4:1). The articular chondrocytes, under these conditions of culture, thus apparently produced a collagen resembling that of skin and cultured cutaneous fibrocytes having a chain composition [α1(I)] 2α2.
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