Abstract
Abstract: The collagen profile was studied in 2–3 week old granulation tissue, induced in rats by subcutaneous implantation of viscose cellulose sponges. Cyclophosphamide was given daily intraperitoneally, in a dose of 10 mg per kg during the entire experiment, beginning either 7 days before or on the day of the sponge implantation. Cyclophosphamide caused an increase in the water percentage, and decreased the dry weight and the total amount of collagen in the granulomas, reflecting a suppression of collagen synthesis. The catabolism of collagen was also inhibited in the cyclophosphamide treated rats, as indicated by a fall in the content of free OH‐proline and a lowering of the alpha/beta ratio in acid extracted collagen. Cyclophosphamide treatment increased the collagen solubility in acetic acid and increased the aldehyde content in relation to OH‐proline in purified collagen. This indicates that cyclophosphamide may inhibit the cross‐linking of collagen by blocking the aldehydes or decrease the stability of the collagen molecule by decreasing the hydroxylation of proline. Pretreatment with cyclophosphamide did not influence the effect of cyclophosphamide given during the development of granulation tissue.
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