Abstract
Abstract The effect of collagen peptides (CPs) administration in early basic enteral nutrition (EN) intervention after burn injury on intestinal barrier function was investigated in mice model. Burn-induced increases of intestinal permeability and disruption of intestinal barrier integrity were significantly attenuated by CPs supplemented EN at post-burn day 1, 3 and 7 as compared with only basic EN fed group. CPs revealed a prominent amelioration of the expression and localization of tight junction protein ZO-1 and occludin in intestinal mucosa. Furthermore, CPs administration significantly inhibited burn-induced elevation of MLCK expression and MLC phosphorylation. Simultaneously, the activation of involved signal pathways, such as NF-κB p65, MAPK p38, ERK and JNK were diminished in different extent by CPs addition. Therefore, CPs could be considered as a beneficial adjunct in early EN intervention to prevent intestinal barrier disruption following burn injury, because of its protective effects on intestinal tight junction integrity.
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