Abstract
The aim of this study was to examine and evaluate morphometrically age-related changes in collagen network in the tunica media of human basilar artery. Histological analysis of the basilar arteries obtained from 89 individuals, aged 20 to 85 years, was performed. The study has been carried out by standard histological technique; histological samples were stained with picrosirius red. Detailed quantitative analysis of collagen bundle network in the tunica media of basilar artery was performed. We analyzed collagen network area, perimeter and number of collagen bundles in the tunica media of the basilar artery. After investigation of age-related changes in collagen network area in men and women, we determined that in both genders collagen network area in the tunica media of the basilar artery increased with age. Analyzing the perimeter and number of collagen bundles in both genders by different age groups, it was found that they decreased with age. We found a statistically significant correlation between all the measured parameters and the age. The area of collagen bundles increased, the number and perimeter of collagen bundles decreased with age in both genders in the tunica media of human basilar artery. While aging, the structure of collagen bundle network became less branchy, collagen fibers merged, their cross section area enlarged.
Highlights
One of the main hallmarks of arterial aging is arterial wall remodeling, which is the outcome of degenerative processes, and involves adaptive and compensatory processes [1]
The area of collagen bundles increased, the number and perimeter of collagen bundles decreased with age in both genders in the tunica media of human basilar artery
Analysis of female groups showed that there was a significant difference in collagen network area in the tunica media of the basilar artery between all age groups (P
Summary
One of the main hallmarks of arterial aging is arterial wall remodeling, which is the outcome of degenerative processes, and involves adaptive and compensatory processes [1]. The collagen, elastin, and smooth muscle contents of the tunica media and the geometrical arrangement of arterial wall components are constantly modified according to the subjects age. These morphometric changes are responsible for changes in the mechanical properties of the arterial walls leading to rigidity [5, 6]. The diameter of the vessels tends to increase It partially compensates for the effects of arterial wall rigidity on vascular compliance, thereby limiting the hemodynamic and functional changes that occur in blood circulation [6, 7]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
