Collagen membrane controlled transdermal delivery of propranolol hydrochloride

Abstract

Membrane permeation controlled-transdermal delivery systems for propranolol hydrochloride were developed using collagen membranes as rate-controlling membranes. Collagen extracted from fetal calf skin was used for this purpose. The ability of the transdermal devices to deliver the drug while supported on rabbit pinna skin was evaluated by conducting in vitro studies using modified Franz diffusion cells. The drug release profiles show that the drug delivery is well controlled by the devices. The drug release rate from the devices was found to depend on the permeability of the membrane used.