Abstract
Wounds represent a major healthcare problem especially in hospital-associated infections where multi-drug resistant strains are often involved. Nowadays, biomaterials with therapeutic molecules play an active role in wound healing and infection prevention. In this work, the development of collagen hydrogels loaded with silver nanoparticles and Cannabis sativa oil extract is described. The presence of the silver nanoparticles gives interesting feature to the biomaterial such as improved mechanical properties or resistance to collagenase degradation but most important is the long-lasting antimicrobial effect. Cannabis sativa oil, which is known for its anti-inflammatory and analgesic effects, possesses antioxidant activity and successfully improved the biocompatibility and also enhances the antimicrobial activity of the nanocomposite. Altogether, these results suggest that this novel nanocomposite biomaterial is a promising alternative to common treatments of wound infections and wound healing.
Highlights
Loss of skin integrity because of injury or illness may result in substantial physiologic imbalance
The incorporation of silver nanoparticles in collagen hydrogels synthesized without the use of chemical crosslinking agents resulted in a sustained release of silver ions, leading to prolonged antimicrobial activity
Our bactericidal material exhibited enhanced mechanical properties due to the addition of AgNPs and showed increased stability against enzymatic collagenase degradation which could encourage the application of the dressings
Summary
Loss of skin integrity because of injury or illness may result in substantial physiologic imbalance. The loss of the skin barrier function due to impaired wound healing facilitates the development of microbial communities leading to infection of dermal wounds. These open wounds represent a major healthcare problem especially in hospital-associated infections where multi-drug resistant strains are often involved. A broad range of biomaterial scaffolds has been developed to facilitate the restoration of the skin tissue favoring cellular attachment, proliferation, and differentiation [1–3]. The goal is to restore the functional and structural properties of the wounded tissue to the before injury levels
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