Abstract
Background The safety of radiotherapy techniques in the treatment of vestibular schwannoma (VS) shows a high rate of tumor control with few side effects. Neuropeptide Y (NPY) may have a potential relevance to the recurrence of VS. Further research is still needed on the key genes that determine the sensitivity of VS to radiation therapy. Materials and Methods Transcriptional microarray data and clinical information data from VS patients were downloaded from GSE141801, and vascular-related genes associated with recurrence after radiation therapy for VS were obtained by combining information from MSigDB. Logistics regression was applied to construct a column line graph prediction model for recurrence status after radiation therapy. Pan-cancer analysis was also performed to investigate the cooccurrence of these genes in tumorigenesis. Results We identified eight VS recurrence-related genes from the GSE141801 dataset. All of these genes were highly expressed in the VS recurrence samples. Four collagen family genes (COL5A1, COL3A1, COL4A1, and COL15A1) were further screened, and a model was constructed to predict the risk of recurrence of VS. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses revealed that these four collagen family genes play important roles in a variety of biological functions and cellular pathways. Pan-cancer analysis further revealed that the expression of these genes was significantly heterogeneous across immune phenotypes and significantly associated with immune infiltration. Finally, Neuropeptide Y (NPY) was found to be significantly and negatively correlated with the expression of COL5A1, COL3A1, and COL4A1. Conclusions Four collagen family genes have been identified as possible predictors of recurrence after radiation therapy for VS. Pan-cancer analysis reveals potential associations between the pathogenesis of VS and other tumorigenic factors. The relevance of NPY to VS was also revealed for the first time.
Highlights
Vestibular schwannoma (VS) is a benign tumor that originates from the auditory nerve sheath and accounts for 8% to 10% of intracranial tumors with a similar incidence on the left and right sides, and occasionally bilateral [1]
These results suggest that the high expression of these eight differentially expressed genes (DEGs) is associated with recurrence after radiation therapy
Low expression of COL4A1 and COL5A1 was associated with recurrence of vestibular schwannoma, while high expression of Neuropeptide Y (NPY) was associated with recurrence of vestibular schwannoma (Table 6). These genes were not significantly associated with age and sex (Figures 9(b) and 9(c)). These results suggest that NPY is significantly associated with four collagen family genes (COL3A1, COL4A1, COL5A1, and COL15A1) and recurrence after radiotherapy for vestibular schwannoma
Summary
Vestibular schwannoma (VS) is a benign tumor that originates from the auditory nerve sheath and accounts for 8% to 10% of intracranial tumors with a similar incidence on the left and right sides, and occasionally bilateral [1]. Neuropeptide Y (NPY) may have a potential relevance to the recurrence of VS. Transcriptional microarray data and clinical information data from VS patients were downloaded from GSE141801, and vascular-related genes associated with recurrence after radiation therapy for VS were obtained by combining information from MSigDB. We identified eight VS recurrence-related genes from the GSE141801 dataset. Four collagen family genes (COL5A1, COL3A1, COL4A1, and COL15A1) were further screened, and a model was constructed to predict the risk of recurrence of VS. Pan-cancer analysis further revealed that the expression of these genes was significantly heterogeneous across immune phenotypes and significantly associated with immune infiltration. Four collagen family genes have been identified as possible predictors of recurrence after radiation therapy for VS. Pan-cancer analysis reveals potential associations between the pathogenesis of VS and other tumorigenic factors. The relevance of NPY to VS was revealed for the first time
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