Abstract
The treatment of large-area bone defects remains a challenge; however, various strategies have been developed to improve the performances of scaffolds in bone tissue engineering. In this study, poly(lactide-co-glycolide)/hydroxyapatite (PLGA/HA) scaffold was coated with Asp-Gly-Glu-Ala (DGEA)-incorporated collagen for the repair of rat skull defect. Our results indicated that the mechanical strength and hydrophilicity of the PLGA/HA scaffold were clearly improved and conducive to cell adhesion and proliferation. The collagen-coated scaffold with DGEA significantly promoted the repair of skull defect. These findings indicated that a combination of collagen coating and DGEA improved scaffold properties for bone regeneration, thereby providing a new potential strategy for scaffold design.
Highlights
Partial or large bone resection is needed for the treatment of bone tissue lesions caused by trauma, tumors, and other diseases
Scanning electron microscopy revealed that the pore size of the scaffold was uniform, some pores were perforated, and the inner wall was smooth (Figure 1A), which contributed to cell adhesion and substance exchange [11,12]
Our results indicated a coarser inner wall of the coated scaffold, which would be more conducive to cell adhesion (Figure 1B,C)
Summary
Partial or large bone resection is needed for the treatment of bone tissue lesions caused by trauma, tumors, and other diseases. Postoperative bone recovery is often poor, resulting in delayed healing, nonunion, and poor bone regeneration, which poses great challenges in the fields of orthopedics and stomatology [1]. One of the three elements of tissue engineering, play an important role in bone repair [2]. The bone tissue engineering scaffolds currently used by researchers mainly include biodegradable polymer materials, titanium alloys, and calcium phosphate [3]. For the polymer materials, their low biological activity, poor tissue-cell compatibility, and slow or nonexistent biodegradation lead to poor therapeutic efficacy, requiring these scaffolds to be often removed in a second surgery, which places great physical and financial burdens
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