Abstract
Collagen is the most widely distributed class of proteins in the human body. The use of collagen-based biomaterials in the field of tissue engineering applications has been intensively growing over the past decades. Multiple cross-linking methods were investigated and different combinations with other biopolymers were explored in order to improve tissue function. Collagen possesses a major advantage in being biodegradable, biocompatible, easily available and highly versatile. However, since collagen is a protein, it remains difficult to sterilize without alterations to its structure. This review presents a comprehensive overview of the various applications of collagen-based biomaterials developed for tissue engineering, aimed at providing a functional material for use in regenerative medicine from the laboratory bench to the patient bedside.
Highlights
During the past decade, numerous innovations occurred in the field of collagen-based biomaterials.From injectable collagen matrices to bone regeneration scaffolds, production and cross-linking methods have evolved and improved
The collagenolytic activity of all these matrix metalloproteinase (MMP) rely on three principles: the ability to bind collagen molecules, the ability to unwind the three α chains and the ability to cleave each strand of the triple helix [39]
Crosslinking techniques are especially important for collagen-based biomaterials when compared to acellular collagen matrices that have already been polymerized in vivo
Summary
Numerous innovations occurred in the field of collagen-based biomaterials. From injectable collagen matrices to bone regeneration scaffolds, production and cross-linking methods have evolved and improved. Collagen is widely used in both research environments and medical applications. A brief introduction of the collagen molecule will be presented, followed by some technical explanation covering collagen scaffold production methods. The recent advances that have been developed in collagen-based tissue-engineering biomaterials will be discussed
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
