Abstract
This study was undertaken to investigate the effects on ovarian function, bleeding control and plasma levels of d-norgestrel (d-Ng) in women using Silastic intravaginal rings designed to deliver steroid from a collagen band impregnated with d-Ng and estradiol benzoate (EB). Bands containing d-Ng at two different concentration levels were used. The estradiol levels in plasma were not affected by the EB content of the IVRs. Ovulation occurred in one out of eighteen cycles studied. Breakthrough bleeding or spotting occurred in 18 per cent of the treatment days and was more common with IVRs of a lower d-Ng content. Higher but more variable plasma levels of d-Ng were observed in subjects using IVRs of the higher d-Ng content. After removal of the IVR an elimination half life for d-Ng of 18.9 hours was found. It is concluded that collagen can be used for vaginal administration of d-Ng but that EB does not affect the estradiol plasma levels or the incidence of breakthrough bleeding.
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