Abstract
The normal development of collagen and its relation to ventricular enlargement was studied in the fetus and after birth in the rabbit. During development the total collagen mass increases to the same degree in each ventricle independently of the muscle mass. At birth the concentration of collagen is the same in each ventricle. Thereafter, with greater muscular development in the left than the right ventricle, the concentration of collagen in the right ventricle comes to exceed that in the left. In the mature animal the concentration of collagen in the atria is considerably greater than that in the ventricles.
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