Abstract
BEILLY, J. S. Determination of the pH of the vaginal fluid as an objective method of observation in administration of estrogens. To appear in this Journal. A simple test is offered which can be employed as a guide in treatment with estrogens in human castrate, menopausal and hypo-ovarian female groups by following the changes in pH of the vaginal contents. This determination is carried out by adding to the sample of the vaginal contents the universal indicator, and the pH is detected by a color change. Objective and subjective improvement, following administration of adequate amounts of estrogens, is predictable and will be noted with approach of the normal, acid phase of contents. The change in pH occurs concomitantly with improvement in cytology of the vaginal smear, after administration of estrogens. The pH method can be used as an office procedure, and is a guide in estrogenic medication.
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