Abstract
This is the first report to test the loading dosage of colistin against Pseudomonas aeruginosa, including MDRP. Using invivo murine thigh infection model, in the loading dosage regimen (Day 1:50mg/kg q12h, Day 2-3: 25mg/kg q12h) group, 5 to 6 log10CFU/ml reduction compared with control were observed for both strains of P.aeruginosa with colistin MIC 0.5 and 1μg/mL at 72h. But, similar reduction was observed for the strains with colistin MIC 0.5μg/mL only in normal dosage regimen (Day 1-3: 25mg/kg q12h) group. For P.aeruginosa with colistin MIC 1μg/mL, colistin loading dosage regimens showed greater antimicrobial activity than that of without loading dosage group (p<0.05). These data suggest that the colistin loading regimen would be one of the useful options for P.aeruginosa with antimicrobial resistance infection treatment.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
