Abstract
It should be remembered that bacteria continue to spread and develop new types of resistance, so further actions are needed to deal with antibiotic resistance. As a result, antibacterial drugs have become less effective, resulting in the accelerated discovery of available alternative treatments, including essential oils. The aim of this work was to intensify and promote the action of two antibiotics, kanamycin, and colistin, to fight antibiotic resistance thanks to the action of essential oil obtained from the flowers of Coridothymus capitatus grown on the Iblei mountains. To this end, a comparison of biological and chemical assays was carried out. The results showed a broad antimicrobial power of the essential oil itself and a great synergistic activity in combination with Kanamycin and Colistin against multidrug-resistant bacteria. These combinations increased the range of antibiotics, leading us to speculate that it could be incorporated into new pharmaceutical formulations for therapies of infections caused by increasingly dangerous bacteria. Antibiotic resistance represents an ever-greater danger to human health. This work re-evaluates the use of colistin and kanamycin thanks to the synergistic action found with the addition of a natural substance to pave the way for new therapeutic strategies.
Highlights
The International Organization for Standardization defines Essential Oils (EOs) as products obtained from raw vegetable material by distillation, mechanical process or dry distillation [1]
Chemical analysis performed on TEO obtained from the flowers of Coridothymus capitatus (L.) Richb.f grown in Lauretum-Rosmarinetum located in the southwest of the Aleppo pine reserve on Iblei mountains (Ragusa, Sicily) showed a very peculiar chemotype
The triple combination KAN+COL+TEO caused a total inhibition of growth for E. coli, P. aeruginosa and A. baumannii at the following concentration: 0.12 COL – 2.0 KAN – 47.12 TEO μg/mL
Summary
The International Organization for Standardization defines Essential Oils (EOs) as products obtained from raw vegetable material by distillation, mechanical process or dry distillation [1]. Biological properties of EOs have been known since a long time. Numerous studies in the literature confirm their action (in vitro and in vivo) [2-6]. These activities can be attributed to a large number of molecules such as terpenoids and phenolic compounds, which show antimicrobial activity even when they are tested in the pure form [710] as regard Coridothymus capitatus is a plant belonging to the family Lamiaceae. Thymus essential oils are used in clinical as a supplement to conventional medical therapy and in veterinary medicine for dogs, cats, cattle, and sheep (diluted in sweet almond oil) [15]. TEO has been shown to have antiparasitic [16, 17], insecticidal [18], and antifungal [19] as well as antibacterial activity
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