Abstract
Neutralization of bacteriophage T2 by 19S and 7S fractions or rabbit antisera was studied in the presence and absence of isolated human C1. Neutralization by 19S antibody is not effected by addition of C1. Neutralization of the phage by 7S antibody, however, is markedly increased by addition of C1. Ammonia treatment of both the 7S antibody and the C1 preparations to inactive C4 did not reduce the ability of C1 to enhance neutralization. Heat treatment of C1 at 56°C for 30 min, however, did inactivate the enhancing factor as did treatment with EDTA. When added individually in the presence of antibody, the other isolated C components (C4, 2, 3, 5, 6, 7, 8, 9) were ineffective in the neutralization of T2.
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