Abstract
Supranodose vagotomy was performed in cats. These cats were kept for 11 to 31 days. Gastric motility was recorded with a balloon method. Electrical stimulation of vagal trunk on the operated side caused an excitatory response of the stomach. Administration of hexamethonium (C6) (10 mg/kg i.v.) inhibited the excitatory response. The second administration of C6 did not inhibit the response but augmented it. The excitatory response was dose-dependently inhibited by administration of atropine (3 and 30 μg/kg i.V.). It was concluded that the excitatory response of vagal trunk in cats with chronic supranodose vagotomy is due to activation of the fibers originating from the nodose ganglion,and the pharmacological nature of the fibers is cholinergic, activating nicotinic as well as muscarinic receptors. The augmentation of the excitatory response with the second administration of hexamethonium may be due to inhibition of an activity of inhibitory neurons in the gastric walls.
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