Cold-inducible RNA-binding protein but not its antisense lncrna is a direct negative regulator of angiogenesis via regulation of the 14q32 angio-miRs—microRNA-329-3p and microRNA-495-3p

Abstract

Background and Aims : Inhibition of the 14q32 microRNAs, miR-329-3p and miR-495-3p, improves post-ischemic neovascularization. Cold-inducible RNA-binding protein (CIRBP) facilitates maturation of these microRNAs. We hypothesized that CIRBP deficiency improves post-ischemic angiogenesis, including intraplaque angiogenesis, via downregulation of 14q32 microRNA expression.