Abstract
Ovarian cancer (OC) is a gynecologic tumor with poor prognosis. Despite radical cytoreductive surgery and platinum-based adjuvant systemic treatment, OC will relapse in the majority of the cases. Thus, cold atmospheric plasma (CAP), a highly reactive physical state bearing diverse biological activities being suited for anticancer therapy, may be a promising option in OC therapy. OC cell lines were exposed either directly to the CAP or to cell culture medium previously exposed to CAP. Cell proliferation and cell motility was measured. The data demonstrated, that even a single application of a short-term CAP treatment led to an attenuation of OC cell growth and motility. Moreover, incubation with CAP-treated cell culture medium gave similar effects. Results were consistent in four OC cell lines. In summary, the CAP application in oncological surgery leads to strong anti-proliferative effects and opens up novel opportunities for the OC treatment.
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