Abstract
Rats with incised and sutured wounds and having subcutaneously implanted polyvinyl alcohol sponges were treated with various doses of colchicine. Breaking strength of wound tissue and biochemical analysis of sponge-induced granuloma tissue were compared with similar measurements in pair-fed controls. Colchicine reduced breaking strength of wound scar tissue significantly while lysyl oxidase activity in sponge tissue was not affected. Synthesis of collagenous and noncollagenous protein was stimulated by colchicine but accelerated collagen synthesis did not result in increased deposition of collagen in sponge tissue. The increased urinary excretion of hydroxyproline in colchicine-treated rats was paralleled by loss of body weight. Colchicine-induced cytotoxicity was also identified in fibroblasts from sponge granuloma tissue examined by transmission electron microscopy. We conclude that some reduction of total collagen deposition and breaking strength of wound tissue in colchicine-treated animals may have been the result of general toxicity of the drug. A specific effect of colchicine on collagen metabolism cannot be ruled out.
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