Abstract
Coinciding revolutions: how discovery of non-coding DNA and RNA can change our understanding of addiction.
Highlights
The twenty-first century started with the Big Bang—the first ever sequencing of the human genome in 2000/2003 (Lander et al, 2001; Venter, 2003), and since our scientific Universe started to expand with the speed of light
Several papers described the involvement of different non-coding RNAs, primarily microRNA, in unraveling novel molecular mechanisms of this debilitating disease. We put together this Special Issue of Frontiers in Genetics to provide our readers with a comprehensive overview of current research on non-coding RNA in both drug and alcohol addiction
We invited leaders in this dynamic new field to write a series of reviews, and other prominent scientists to share their views of this subject through a series of editorials. This special issue is divided into five chapters: alcohol, nicotine, cocaine, morphine, and bioinformatics
Summary
The twenty-first century started with the Big Bang—the first ever sequencing of the human genome in 2000/2003 (Lander et al, 2001; Venter, 2003), and since our scientific Universe started to expand with the speed of light. The project indicates that the vast majority (99%) of the human genome, non-coding, is not “junk” but is biologically active and essential to maintain fundamental processes in a cell (Bernstein et al, 2012). Several papers described the involvement of different non-coding RNAs, primarily microRNA, in unraveling novel molecular mechanisms of this debilitating disease.
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