Abstract

The possibility that some of the regularities shown by amino acid sequences might be due to chance has been studied. Random sequences corresponding to ribonuclease, tobacco mosaic virus protein, trypsinogen, chymotrypsinogen and the A and B chains of haemoglobin were examined for the presence of intramolecular repeats of peptides and for peptide units present in more than one sequence. None of these proteins differed from random sequences with respect to intramolecular repeats. In the parts of their sequences now known the pairs of proteins trypsinogen and chymotrypsinogen, A chain and B chain of haemoglobin have more common peptide units than do the corresponding random sequences. The dipeptide frequencies in 13 proteins and peptides show no departure from randomness.

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