Abstract
A molecular machine like myosin needs to work in cycles and resists the possibility of an overload. A critical component of myosin is the coiled-coli structure of two amphipathic alpha helices that helps transmit load and are found in a wide range of motor and structural proteins. What are the mechanical benefits of the coiled-coil structure and the specific sequence design found in the myosin protein? In this talk I will discuss a “load release valve” that is naturally designed into the coiled-coil sequence and structure. The valve responds to external load and undergoes significant conformational transition to reduce load levels and strain ensuring that a recovery path (and closure of the valve when appropriate) is simple, reliable and remarkably fast.
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