Cohort study of risk factors between patients with lung cancer complicated with acute pulmonary embolism and those with lung cancer alone

Abstract

Objective To evaluate the clinical features, prognosis and risk factors of pulmonary thromboembolism in patients with lung cancer complicated with acute pulmonary embolism (APE). Methods A total of 58 patients with APE and lung cancer admitted in Beijing Shijitan Hospital between January 2010 to December 2017 were retrospective enrolled as the APE group and 116 lung cancer patients with similar age and gender admitted at the same time without APE were in non-APE group. We analyzed the basic and follow-up clinical data. Kaplan-Meier survival analysis and log-rank test was used to assess the median survival time, and univariate and multivariate logistic analysis was used to evaluate the risk factors for APE. Results 174 patients with a mean age of 51.9±18.3 years were enrolled. Baseline characteristics, such as age, male ratio, BMI, medical history, platelet counts, hemoglobin were similar between the two groups (P>0.05). However, syncope, blood pressure, heart rate, PaO2, cardiac troponin I, BNP and D-Dimer were significantly different between the two groups (P 0.05). Multivariate logistic regression analysis showed that advanced age, tumor stages Ⅲ-Ⅳ, surgery and deep vein catheterization were risk factors for APE (all P<0.05). Conclusions Lung cancer patients complicated with APE have higher risk of mortality. Advanced age, tumor stages Ⅲ-Ⅳ, surgery and deep vein catheterization are risk factors for APE. Key words: Acute pulmonary embolism; Lung cancer; Prognosis; Risk factor