Abstract
Institution and country of all co-authors (1) Swiss Paediatric Respiratory Research Group, Department of Social and Preventive Medicine, University of Berne, Switzerland (2) The Leicester Children's Asthma Centre, Division of Child Health, Department of Infection, Immunity & Inflammation, University of Leicester, Leicester, LE2 7LX, UK (3) Specialist Community Child Health Services, Leicester City PCT, Bridge Park Plaza, Thurmaston, Leicester, LE4 8PQ, UK
Highlights
Asthma and other wheezing disorders are the most common chronic health problems in childhood and place a large burden on children, their families and society.1 Prevalence is highest in infancy or early childhood and the aetiology is complex, with a strong influence of intrauterine and early life exposures
This study provided the first data on prevalence7–9 and subsequently on natural history of preschool wheeze in Europe
Four major aims of the study were: (i) to estimate the prevalence of these respiratory disorders in young children and to determine whether secular trends in asthma and wheeze described for adults and schoolchildren were evident for preschool children; (ii) to study the contribution of potential risk factors on incidence and persistence of wheeze and other respiratory disorders taking into account different age-exposure windows; (iii) to study wheezing disorders in children of south Asian origin, the predominant British ethnic minority and (iv) to study the natural history of wheeze and chronic cough and to determine how many disease phenotypes exist within the ‘asthma’ spectrum in childhood
Summary
Asthma and other wheezing disorders are the most common chronic health problems in childhood and place a large burden on children, their families and society. Prevalence is highest in infancy or early childhood and the aetiology is complex, with a strong influence of intrauterine and early life exposures. Four major aims of the study were: (i) to estimate the prevalence of these respiratory disorders in young children and to determine whether secular trends in asthma and wheeze described for adults and schoolchildren were evident for preschool children; (ii) to study the contribution of potential risk factors on incidence and persistence of wheeze and other respiratory disorders taking into account different age-exposure windows; (iii) to study wheezing disorders in children of south Asian origin, the predominant British ethnic minority and (iv) to study the natural history of wheeze and chronic cough and to determine how many disease phenotypes exist within the ‘asthma’ spectrum in childhood The results of these studies have implications for public health, giving detailed population-based information on respiratory disorders in children, on health care utilization and on treatment, and should lead to preventive interventions. Research from the Leicester cohorts should provide diagnostic algorithms to predict prognosis and facilitate the management of children suffering from wheeze or chronic cough
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