Cohort and Individual Neurodevelopmental Stability between 1 and 6 Years of Age in Children with Congenital Heart Disease

Abstract

To assess cohort and individual neurodevelopmental stability in children with congenital heart disease across childhood. The Reachout Study is a cohort study at the University Children's Hospital Zurich. Data from 148 children with congenital heart disease who underwent cardiopulmonary bypass surgery and 1-, 4-, and 6-year neurodevelopmental assessment were analyzed using mixed models. Cognitive and motor functions of the total cohort improved over time (cognitive: P=.01; motor: P<.001). The prevalence of children with cognitive impairment at age 6years was 22.3%. Socioeconomic status showed a significant interaction with age on cognitive and motor development (cognitive: P<.001; motor: P=.001): higher socioeconomic status was associated with better neurodevelopmental outcome over time. Weight and head circumference at birth showed a significant interaction with age on motor development (weight: P=.048; head: P=.006). The correlation between test scores at different ages was weak to moderate (cognition: age 1-6years: rho=0.20, age 4-6years: rho=0.56, motor: age 1-6years: rho=0.23, age 4-6years: rho=0.50). Children with congenital heart disease show a mild improvement in cognitive and motor functions within the first 6years of life, particularly those with higher socioeconomic status and larger head circumference and weight at birth. However, individual stability is moderate at best. Therefore, follow-up assessments are crucial to target therapeutic intervention effectively.