Cohort analysis for the present mutation of NPM1 in bone marrow cancer

Abstract

DNA is the most important code for deciphering human genetic information. It finally determines proteins through the central dogma. Therefore, gene mutations can cause various diseases. Cancer is one of the most difficult-to-cure diseases caused by mutations. Acute myeloid leukemia is one of the subtypes of bone marrow cancer, this essay will predominantly focus on the study of the mutation gene NPM1 (nucleophosmin 1). In order to understand the differences between the mutated gene NPM1 and other mutated genes, a cohort study analysis of NPM1 is needed. This research helps better understanding of cancer and the variation of NPM1 compared to the others. By researching and analyzing direct clinical data, this essay will contribute to the understanding of cancer and help turn a scientific blank message into a more simple and understandable manner. However, the limitation of this study is insufficient or even missing data. With the development of research and the improvement of data, future studies will be more accurate and effective, providing a more effective reference for exploring targeted therapy of acute myeloid leukemia.