Abstract
Changes in the interactions of the hippocampus and medial septal area in the theta range (4–8 Hz) during the generation of convulsive activity in electrical kindling were studied in conscious guinea pigs. Overall electrical activity (EEG)was analyzed by wavelet transformation. Decreases in the coherence of theta oscillations recorded in both structures were seen during generation of convulsive discharges. Phase analysis showed that the phase-leading structure at the initial stage of epileptogenesis was the medial septal area; however, after formation of the pathological focus, the medial septal area lagged the hippocampus in phase. These data may contribute to our understanding of the mechanisms of development of temporal epilepsy.
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