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Abstract
Introduction: Mild cognitive impairment (MCI) is characterized by cognitive decline, prodromal to dementia. However, no medications currently exist. However, research suggests intervention techniques like exercise and cognitive training to slow MCI-progression. The purpose of this research protocol is to determine whether these intervention techniques work more efficiently in combination or separately. Methods: 80 participants with MCI will be recruited and divided into four groups of 20 participants each; Group-1 will be exposed to cognitive training, Group-2 will be exposed to aerobic exercise, Group-3 will be exposed to both, and Group-4 will be exposed to none. All participants will write a series of cognitive tests that establish a baseline cognition level. After six- months of training, participants will rewrite the tests. An analysis of variance will be done on pre- and post-test scores to identify the strategy that produces the most positive change. Results: Since past literature has found that cognitive training and physical exercise effectively slow cognitive decline, it can be anticipated that a combination of both will be more effective than either intervention alone. It can also be anticipated that all groups involving cognitive training and physical exercise, either alone or in combination, will experience more positive change on their post-test scores than the controls. Discussion: Literature suggests that a combination of two effective interventions may be more effective than either alone; a study examining the impact of two interventions on falls and cognition in individuals with MCI found both interventions together was the most effective treatment. By conducting a longitudinal study involving a Control-group and multiple cognition-screening tests, this protocol enables the investigation of another possible treatment avenue for individuals with MCI. Conclusion: By examining the interaction between two effective treatment methods for MCI, a condition without medications, this study provides individuals with MCI an additional treatment route that may slow cognitive decline. To permit generalization, future studies should be conducted using larger participant pools that are matched for demographic factors.
Highlights
Mild cognitive impairment (MCI) is characterized by cognitive decline, prodromal to dementia
We anticipate that between the Physical Exercise and Control group, the Physical Exercise group would experience a greater increase in pre- and post-test scores relative to the controls, thereby indicating the potential of Physical Exercise to slow cognitive decline
Considering how past literature suggests that both cognitive training [2] and physical exercise [3] are effective strategies in slowing cognitive decline, we can anticipate that both the Cognitive Training and Physical Exercise group would experience a similar increase between pre- and post-test scores
Summary
Mild cognitive impairment (MCI) is characterized by cognitive decline, prodromal to dementia. Research suggests intervention techniques like exercise and cognitive training to slow MCI-progression. Results: Since past literature has found that cognitive training and physical exercise effectively slow cognitive decline, it can be anticipated that a combination of both will be more effective than either intervention alone. It can be anticipated that all groups involving cognitive training and physical exercise, either alone or in combination, will experience more positive change on their post-test scores than the controls. Conclusion: By examining the interaction between two effective treatment methods for MCI, a condition without medications, this study provides individuals with MCI an additional treatment route that may slow cognitive decline. Intervention techniques such as cognitive training [2] and physical exercise [3] can slow the progression of MCI to variable degrees. Research conducted with animal models has demonstrated cognitionenhancing effects attributed to exercise; these effects include improved neuron survivability, vascularization, neuroinflammation, and neuroendocrine responses
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Schedule a callMore From: Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal
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