Cognitive Modeling Suggests That Attentional Failures Drive Longer Stop-Signal Reaction Time Estimates in Attention Deficit/Hyperactivity Disorder.

Abstract

Mean stop-signal reaction time (SSRT) is frequently employed as a measure of response inhibition in cognitive neuroscience research on ADHD. However, this measurement model is limited by two factors which may bias SSRT estimation in this population: 1) excessive skew in "go" RT distributions, and 2) trigger failures, or instances in which individuals fail to trigger an inhibition process in response to the "stop" signal. We use a Bayesian parametric approach, which allows unbiased estimation of the shape of entire SSRT distributions and the probability of trigger failures, to clarify mechanisms of stop-signal task deficits in ADHD. Children with ADHD displayed greater positive skew than their peers in both "go" RT and SSRT distributions. However, they also displayed more frequent trigger failures, which appeared to drive ADHD-related stopping difficulties. Results suggest that stop-signal task performance in ADHD reflects impairments in early attentional processes, rather than inefficiency in the stop process.