Abstract
Background: Cognitive deficits are common in multiple sclerosis (MS) and affect patients at all stages of the disease, regardless of phenotype. Aims: This literature review focuses the cognitive deficits observed in secondary progressive MS (SPMS). It is mainly based on studies that compared the frequency and main characteristics of cognitive deficits in SPMS with other phenotypes. Methods: A bibliographic search was carried out using the PubMed database with the following keywords: multiple sclerosis, secondary-progressive, cognition. Results: Thirteen studies were initially selected that were published in English, reporting the neuropsychological data of a sample of at least 30 patients with SPMS, comparing them with patients with other phenotypes. Studies suggest that there is an association between the duration of the disease and the frequency and extent of the cognitive disorders. Studies also showed that the SP form is associated with an increased frequency of cognitive impairment and with an increased severity as compared to relapsing-remitting MS (RRMS). Compared to RRMS, progressive forms of MS are associated with more severe impairment in certain cognitive areas, such as episodic verbal memory, information processing speed, working memory, or verbal fluency. Two studies showed that cognitive performances decline overtime in SPMS. Conclusion: Cognitive disorders are more frequent and more severe in the SP form than in relapsing course of MS. The profile of cognitive impairment encountered in the SP form also appears to be different from those found in the other phenotypes.
Highlights
About 85% of people with multiple sclerosis (MS) begin their disease with a relapsing phenotype (relapsing-remitting MS (RRMS))
Two types of studies can investigate the link between cognitive disorders and disease duration: cross-sectional studies and longitudinal studies
Regardless of the definition of cognitive impairment of at least two standard deviations from the normal value for the overall cognitive score used or of at least one standard deviation, there was a significant increase in the frequency of cognitive impairment as a function of disease duration
Summary
About 85% of people with multiple sclerosis (MS) begin their disease with a relapsing phenotype (relapsing-remitting MS (RRMS)). An increasing number of disease-modifying drugs are available to treat patients with relapsing-remitting disease, preventing relapses. Despite these treatments, a proportion of patients with RRMS evolves to secondary progressive MS (SPMS) over variable periods of time. This progressive stage is characterized by a continuous worsening of the disability, independent of additional new exacerbations, which may still occur in some patients during this phase. Cognitive deficits are common in multiple sclerosis (MS) and affect patients at all stages of the disease, regardless of phenotype. It is mainly based on studies that compared the frequency and main characteristics of cognitive deficits in SPMS with other phenotypes
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
