Cognitive Impairment and Diminished Neural Responses Constitute a Biomarker Signature of Negative Symptoms in Psychosis

Matthew E Hudgens-Haney,Brett A Clementz,Elena I Ivleva,Matcheri S Keshavan,Godfrey D Pearlson,Elliot S Gershon,Sarah K Keedy,John A Sweeney,Florence Gaudoux,Pierre Bunouf,Benoit Canolle,Françoise Tonner,Silvia Gatti-Mcarthur,Carol A Tamminga

doi:10.1016/j.biopsych.2020.02.327

Cognitive Impairment and Diminished Neural Responses Constitute a Biomarker Signature of Negative Symptoms in Psychosis

Matthew E Hudgens-Haney, Brett A Clementz + Show 12 more

https://doi.org/10.1016/j.biopsych.2020.02.327

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Journal: Biological psychiatry

Publication Date: May 1, 2020

Affiliation: The University of Texas Southwestern Medical Center, Southwestern Medical Center, University of Georgia, Harvard University, Yale University, University of Chicago, University of Cincinnati, Pierre Fabre (Germany)

#Negative Symptoms In Psychosis #Symptoms In Psychosis + Show 8 more

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Abstract

The treatment of negative symptoms (NS) in psychosis represents an urgent unmet medical need given the significant functional impairment it contributes to psychosis syndromes. The lack of progress in treating NS is impacted by the lack of known pathophysiology or associated quantitative biomarkers, which could provide tools for research. This current analysis investigated potential associations between NS and an extensive battery of behavioral and brain-based biomarkers in 932 psychosis probands from the B-SNIP database.

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