Abstract
Objective To assess the effect of hemodialysis(HD), hemodiafiltration(HDF) and hemodialysis(HD) and hemoperfusion(HDP) on the quality of life, cognitive function and nutritional status in chronic renal failure(CRF) patients. Methods All patients were randomly divided into HD, HDF and HDP group.Mini-mental state examination(MMSE), Wisconsin card sorting test (WCST), SF-36 were measured for cognitive function, quality of life and nutrition indicators test. Results After 3, 6 months treatment, MMSE(respectively (22.62±3.85), (25.10±2.26), (25.35±2.44)and (23.87±4.19), (25.10±2.26), (27.19±2.23)), WCST indicators were statistically significant in the three groups(P<0.05); after 1, 3, 6 months treatment, the PF, RP, BP, GH, SF and nutrition indicators were significant difference too(P<0.05); HDP and HDF, HD groups were statistically significant(P<0.05). Conclusion HDF and HDP obviously influence on long-term cognitive function, physical health domains and nutritional status in CRF patients, and superior to HD. Key words: Hemodialysis; Chronic renal failure; Cognitive function; Quality of life; Nutritional status
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