Abstract
(no substance: 27.5±7.5 years; one substance: 28±7.9 years; two substances: 23.4±4.4 years and three substances: 20.4±2.5 years; F=5.8; p=0.000). AGE AT FIRST CONSUMPTION of alcohol (16± 2 years in men vs 15.7±0.8 years in women; F=0.3, p=0.58) and cocaine (18±0.9 years in men vs 20±0 years in women; F=3.7, p=0.06) was not different in men and women. However, men showed a statistically significant earlier age of first consumption of cannabis in comparison to women (16±2.1 years in men vs 18± 3.8 years in women; F=5, p=0.02). Discussion: 1) FEP patients show high rates of substance use, with men significantly consuming more alcohol, cannabis and cocaine than women. 2) An earlier onset of psychosis (7 years earlier) was noted in patients consuming multiple substances. This association was only present in men. 3) Age at first consumption of cannabis was significantly lower for men.
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