Year-end Sale % OFF 
Abstract
BackgroundPlants of the genus Markhamia have been traditionally used by different tribes in various parts of West African countries, including Cameroun. Markhamia tomentosa (Benth.) K. Schum. (Bignoniaceae) is used as an antimalarial, anti-inflammatory, analgesic, antioxidant and anti-Alzheimer agent. The current study was undertaken in order to investigate its anti-amnesic and antioxidant potential on scopolamine-induced cognitive impairment and to determine its possible mechanism of action.MethodsRats were pretreated with the aqueous extract (50 and 200 mg/kg, p.o.), for 10 days, and received a single injection of scopolamine (0.7 mg/kg, i.p.) before training in Y-maze and radial arm-maze tests. The biochemical parameters in the rat hippocampus were also assessed to explore oxidative status. Statistical analyses were performed using two-way ANOVA followed by Tukey’s post hoc test. F values for which p < 0.05 were regarded as statistically significant.ResultsIn the scopolamine-treated rats, the aqueous extract improved memory in behavioral tests and decreased the oxidative stress in the rat hippocampus. Also, the aqueous extract exhibited anti-acetylcholinesterase activity.ConclusionsThese results suggest that the aqueous extract ameliorates scopolamine-induced spatial memory impairment by attenuation of the oxidative stress in the rat hippocampus.
Highlights
Plants of the genus Markhamia have been traditionally used by different tribes in various parts of West African countries, including Cameroun
Air-dried stem bark of M. tomentosa was reduced to fine powder (1000 g) and macerated in 10 L of distilled water for 48 h at room temperature and the mixture was filtered through Whatman filter paper no. 3
In the present study, a series of experiments were designed in order to investigate the cognitive improvement of the aqueous extract from M. tomentosa stem bark in a scopolamine-induced a rat model of cognitive impairment in vivo
Summary
Plants of the genus Markhamia have been traditionally used by different tribes in various parts of West African countries, including Cameroun. The current study was undertaken in order to investigate its anti-amnesic and antioxidant potential on scopolamine-induced cognitive impairment and to determine its possible mechanism of action. Alzheimer’s disease (AD) is considered to be the most common form of dementia relating to memory and cognitive decline. The biochemical hallmarks of AD include the accumulation of the amyloid-beta (Aβ) peptide oligomers and soluble hyperphosphorylated tau proteins [2]. The memory loss and cognitive impairments are strongly related to changes in the acetylcholinesterase (AChE) activity [4]. AChE can increase the rate of fibrillation by binding amyloid-β-associated proteins as potent amyloid-promoting factors [5]. The cholinergic hypothesis led to the development of clinically effective therapeutics for AD [6]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
