Abstract

BackgroundAttention Deficit Hyperactivity Disorder (ADHD) is associated with deficits in different functional domains. It remains unclear if deficits in different domains are equally strong in early childhood, and which deficits are specific to ADHD. Here, we describe functional domains in preschoolers and assess deficits in children with ADHD problems, by comparing them to preschoolers with other mental health problems or who develop typically.MethodsThe ADHD Study assessed 1195 ca. 3.5 years old preschoolers through a semi-structured parent interview, parent questionnaires, and with neuropsychological tests. We determined functional domains by applying factor analytic methods to a broad set of questionnaire- and test-scales. Using resulting factor scores, we employed a Bayesian hierarchical regression to estimate functional deficits in children with ADHD.ResultsWe found that preschoolers’ functioning could be described along the seven relatively independent dimensions activity level and regulation, executive function, cognition, language, emotion regulation, introversion, and sociability. Compared to typically developing preschoolers, those with ADHD had deficits in all domains except introversion and sociability. Only deficits in activity level regulation and executive functions were larger than 0.5 standardised mean deviations and larger than deficits of children with other mental health problems.ConclusionsPreschoolers with ADHD have deficits in multiple functional domains, but only impairments in activity level and regulation and executive functions are specific for ADHD and large enough to be clinically significant. Research on functioning in these domains will be important for understanding the development of ADHD, and for improving treatment and prevention approaches.

Highlights

  • Attention Deficit Hyperactivity Disorder (ADHD) is associated with deficits in different functional domains

  • Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder characterized by symptoms of inattention, impulsivity, and hyperactivity [1], which is associated with deficits in a number of functional domains, including cognition, language, and social behaviour [2,3,4,5]

  • Dimensions of functioning Initial CFAs, for which sub-scales were on theoretical grounds assigned to RDoC domains, did not describe the data sufficiently well

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Summary

Objectives

The aim of this article is to describe functional domains in preschoolers, and to explore how functional profiles of preschoolers with ADHD problems differ from profiles of children with other mental health problems and typically developing controls. The aim of the current study was to describe domains of functioning in preschoolers and to compare functioning of preschoolers with ADHD problems with that of preschoolers with other or no problems

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